Abstract
Using zone electrophoresis, digitoxin binding by serum albumin could not be demonstrated.
Using salt precipitation and dialysis methods, results obtained in the radiotracer portion of the present study agree qualitatively but not quantitatively with those of previous workers who found that digitoxin binding by serum proteins is correlated with albumin content of protein fractions.
When doses within the "therapeutic" range are used, 1 mg of rat serum protein will bind 0.01 µg of digitoxin.
Footnotes
- Received May 8, 1958.
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