Abstract
Oxyphenonium is slowly metabolized by liver slices of the rat, mouse and dog and is slowly metabolized in the intact mouse. The intestinal absorption of oxyphenonium begins rapidly but reaches a maximum between 1 and 2 hours (18 per cent of the total dose) and does not continue to be appreciably absorbed beyond this time. The tissue distribution of oxyphenonium is primarily limited to the kidney, liver and small intestine, reaching the latter via biliary excretion. After oral administration less than 1 per cent of the dose is recovered in the urine while after intravenous administration 32 per cent is recoverable. Oxyphenonium is excreted in the urine by a combination of glomerular filtration and tubular secretion.
Results of studies of intestinal absorption, biliary excretion and complex formation of a number of analogues of oxyphenonium are also included.
Footnotes
- Received April 6, 1957.
JPET articles become freely available 12 months after publication, and remain freely available for 5 years.Non-open access articles that fall outside this five year window are available only to institutional subscribers and current ASPET members, or through the article purchase feature at the bottom of the page.
|