Abstract
d-Lysergic acid diethylamide (LSD) and its brom derivative (BOL), in larger dosage, effectively antagonized pressor-depressor responses to serotonin in rats. In cats, they showed slight and irregular activity against systemic responses to serotonin and, in dogs, BOL exhibited weak and inconstant activity. The vasoconstrictor responses to serotonin in a perfused extremity were also poorly antagonized by BOL; antagonistic activity, when present, was nonspecific. BOL, like ergotamine, failed also to prevent the chemoceptor stimulant action of serotonin in dogs.
BOL caused sharp and partly sustained fall in arterial pressure when given by quick injection to anesthetized rats. This effect was less marked in cats and dogs. LSD caused rises in pressure in rats and small falls in pressure in cats. Inactivation of the sympathetic nervous system enhanced the pressor response to LSD and diminished the depressor effect of BOL in rats and diminished the depressor effect of BOL and LSD in cats.
LSD or BOL given chronically by mouth had no effect on arterial pressures of chronic renal or neurogenic hypertensive dogs.
Footnotes
- Received September 13, 1956.
JPET articles become freely available 12 months after publication, and remain freely available for 5 years.Non-open access articles that fall outside this five year window are available only to institutional subscribers and current ASPET members, or through the article purchase feature at the bottom of the page.
|