Abstract
Reserpine, labeled with carbon-14 in the carboxyl group of the trimethoxybenzoyl moiety, has been prepared and its metabolism studied in the mouse. The drug was given at equi-effective ptotic doses of 96 micrograms/mouse orally and 6 micrograms/mouse intravenously. Reserpine, whether given orally or intravenously, is rapidly metabolized; 30-40 per cent of the dose appears in the urine as trimethoxybenzoic acid within four hours. Fecal excretion of unchanged reserpine is about 8 per cent after an oral dose of 96 micrograms and about 35 per cent after an intravenous dose of 6 micrograms.
The authors wish to express their appreciation to Dr. J. C. Burke and Dr. B. Rubin for helpful discussion during the course of this work.
Footnotes
- Received July 18, 1955.
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