Abstract
A pharmacologic comparison of a p-alkoxy substituted basic ester of benzilic acid and a p-alkoxy basic propiophenone has revealed the following: a. Both possess local anesthetic activity, the benzilic acid ester being more potent, but slower in onset of action and more irritant. b. Neither possesses cholinolytic nor cholinergic properties. c. Both depress arterial pressure partially by decreasing cardiac output and by "direct" vasodilatation.
Studies in man with 4n-butoxy β-(1-piperidyl) propiophenone (dyclonine) indicate that it is a highly effective relatively non-irritating surface anesthetic agent, which can safely be employed in ophthalmic surgery.
Footnotes
- Received July 18, 1955.
JPET articles become freely available 12 months after publication, and remain freely available for 5 years.Non-open access articles that fall outside this five year window are available only to institutional subscribers and current ASPET members, or through the article purchase feature at the bottom of the page.
|
Log in using your username and password
Purchase access
You may purchase access to this article. This will require you to create an account if you don't already have one.