Abstract
The levorotatory isomers of 5-ethyl-5-phenyl hydantoin (Nirvanol) and of 3-methyl-5-ethyl-5-phenyl hydantoin (Mesantoin) are more active as anesthetics in mice than are their respective antipodes.
l-Nirvanol anesthetizes mice in lower dosage than does the corresponding Mesantoin isomer.
d-Kirvanol disappears from the plasma of the rat much more rapidly than does l- and produces a briefer anesthesia in mice than does l-.
l-Mesantoin is demethylated by the rat at a greater rate than is its isomer.
Species differences in the physiological disposition of Nirvanol and Mesantoin are discussed.
Footnotes
- Received August 31, 1953.
- 1954 by The American Society for Pharmacology and Experimental Therapeutics
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