Research ArticleCardiovascular
The selexipag active metabolite ACT-333679 displays strong anti-contractile and anti- remodeling effects, but low β-arrestin recruitment and desensitization potential
John Gatfield, Katalin Menyhart, Daniel Wanner, Carmela Gnerre, Lucile Monnier, Keith Morrison, Patrick Hess, Marc Iglarz, Martine Clozel and Oliver Nayler
Journal of Pharmacology and Experimental Therapeutics May 5, 2017, jpet.116.239665; DOI: https://doi.org/10.1124/jpet.116.239665
John Gatfield
Actelion Pharmaceuticals Ltd.
Katalin Menyhart
Actelion Pharmaceuticals Ltd.
Daniel Wanner
Actelion Pharmaceuticals Ltd.
Carmela Gnerre
Actelion Pharmaceuticals Ltd.
Lucile Monnier
Actelion Pharmaceuticals Ltd.
Keith Morrison
Actelion Pharmaceuticals Ltd.
Patrick Hess
Actelion Pharmaceuticals Ltd.
Marc Iglarz
Actelion Pharmaceuticals Ltd.
Martine Clozel
Actelion Pharmaceuticals Ltd.
Oliver Nayler
Actelion Pharmaceuticals Ltd.
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Research ArticleCardiovascular
The selexipag active metabolite ACT-333679 displays strong anti-contractile and anti- remodeling effects, but low β-arrestin recruitment and desensitization potential
John Gatfield, Katalin Menyhart, Daniel Wanner, Carmela Gnerre, Lucile Monnier, Keith Morrison, Patrick Hess, Marc Iglarz, Martine Clozel and Oliver Nayler
Journal of Pharmacology and Experimental Therapeutics May 5, 2017, jpet.116.239665; DOI: https://doi.org/10.1124/jpet.116.239665
Research ArticleCardiovascular
The selexipag active metabolite ACT-333679 displays strong anti-contractile and anti- remodeling effects, but low β-arrestin recruitment and desensitization potential
John Gatfield, Katalin Menyhart, Daniel Wanner, Carmela Gnerre, Lucile Monnier, Keith Morrison, Patrick Hess, Marc Iglarz, Martine Clozel and Oliver Nayler
Journal of Pharmacology and Experimental Therapeutics May 5, 2017, jpet.116.239665; DOI: https://doi.org/10.1124/jpet.116.239665
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