Research ArticleCardiovascular
Characterization and prediction of cardiovascular effects of fingolimod and siponimod using a systems pharmacology modelling approach
Nelleke Snelder, Bart A Ploeger, Olivier Luttringer, Dean F Rigel, Randy L Webb, David Feldman, Fumin Fu, Michael Beil, Liang Jin, Donald R Stanski and Meindert Danhof
Journal of Pharmacology and Experimental Therapeutics December 1, 2016, jpet.116.236208; DOI: https://doi.org/10.1124/jpet.116.236208
Nelleke Snelder
1 LAP&P consultatnts BV, Leiden, the Netherlands;
Bart A Ploeger
2 Division of Pharmacology, Leiden Academic Centre for Drug Research, the Netherlands;
Olivier Luttringer
3 Modeling and Simulation Department, Novartis, Basel, Switzerland;
Dean F Rigel
4 Cardiovascular and Metabolism Research, Novartis Institutes for Biomedical Research;
Randy L Webb
5 Cardiovascular Clinical Development, Novartis Pharmaceuticals Corporation, East Hanover, New Jersey;
David Feldman
4 Cardiovascular and Metabolism Research, Novartis Institutes for Biomedical Research;
Fumin Fu
4 Cardiovascular and Metabolism Research, Novartis Institutes for Biomedical Research;
Michael Beil
4 Cardiovascular and Metabolism Research, Novartis Institutes for Biomedical Research;
Liang Jin
4 Cardiovascular and Metabolism Research, Novartis Institutes for Biomedical Research;
Donald R Stanski
3 Modeling and Simulation Department, Novartis, Basel, Switzerland;
Meindert Danhof
6 Leiden Academic Center for Drug Research
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Research ArticleCardiovascular
Characterization and prediction of cardiovascular effects of fingolimod and siponimod using a systems pharmacology modelling approach
Nelleke Snelder, Bart A Ploeger, Olivier Luttringer, Dean F Rigel, Randy L Webb, David Feldman, Fumin Fu, Michael Beil, Liang Jin, Donald R Stanski and Meindert Danhof
Journal of Pharmacology and Experimental Therapeutics December 1, 2016, jpet.116.236208; DOI: https://doi.org/10.1124/jpet.116.236208
Research ArticleCardiovascular
Characterization and prediction of cardiovascular effects of fingolimod and siponimod using a systems pharmacology modelling approach
Nelleke Snelder, Bart A Ploeger, Olivier Luttringer, Dean F Rigel, Randy L Webb, David Feldman, Fumin Fu, Michael Beil, Liang Jin, Donald R Stanski and Meindert Danhof
Journal of Pharmacology and Experimental Therapeutics December 1, 2016, jpet.116.236208; DOI: https://doi.org/10.1124/jpet.116.236208
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