Research ArticleNeuropharmacology
Establishing the relationship between in vitro potency, pharmacokinetic and pharmacodynamic parameters in a series of orally available, hydroxyethylamine-derived β-secretase inhibitors
Stephen Wood, Paul H Wen, Jianhua Zhang, Li Zhu, Yi Luo, Safura Babu-Khan, Kui Chen, Roger Pham, Joel Esmay, Thomas A Dineen, Matthew R Kaller, Matthew M Weiss, Stephen A Hitchcock, Martin Citron, Wenge Zhong, Dean Hickman and Toni Williamson
Journal of Pharmacology and Experimental Therapeutics August 21, 2012, jpet.112.197954; DOI: https://doi.org/10.1124/jpet.112.197954
Stephen Wood
1 Amgen;
Paul H Wen
1 Amgen;
Jianhua Zhang
1 Amgen;
Li Zhu
1 Amgen;
Yi Luo
1 Amgen;
Safura Babu-Khan
1 Amgen;
Kui Chen
1 Amgen;
Roger Pham
1 Amgen;
Joel Esmay
1 Amgen;
Thomas A Dineen
1 Amgen;
Matthew R Kaller
1 Amgen;
Matthew M Weiss
1 Amgen;
Stephen A Hitchcock
2 Envoy Therapeutics;
Martin Citron
3 UCB Pharma
Wenge Zhong
1 Amgen;
Dean Hickman
1 Amgen;
Toni Williamson
1 Amgen;
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Table 1. Compound PD effects were binned into 3 categories...
Table 2. The dynamic ranges of measurement for drug and Abeta40 in CSF, plasma and brain homogenate are shown...
- Supplemental Tables -
Table 1. Compound PD effects were binned into 3 categories...
In this issue
Research ArticleNeuropharmacology
Establishing the relationship between in vitro potency, pharmacokinetic and pharmacodynamic parameters in a series of orally available, hydroxyethylamine-derived β-secretase inhibitors
Stephen Wood, Paul H Wen, Jianhua Zhang, Li Zhu, Yi Luo, Safura Babu-Khan, Kui Chen, Roger Pham, Joel Esmay, Thomas A Dineen, Matthew R Kaller, Matthew M Weiss, Stephen A Hitchcock, Martin Citron, Wenge Zhong, Dean Hickman and Toni Williamson
Journal of Pharmacology and Experimental Therapeutics August 21, 2012, jpet.112.197954; DOI: https://doi.org/10.1124/jpet.112.197954
Research ArticleNeuropharmacology
Establishing the relationship between in vitro potency, pharmacokinetic and pharmacodynamic parameters in a series of orally available, hydroxyethylamine-derived β-secretase inhibitors
Stephen Wood, Paul H Wen, Jianhua Zhang, Li Zhu, Yi Luo, Safura Babu-Khan, Kui Chen, Roger Pham, Joel Esmay, Thomas A Dineen, Matthew R Kaller, Matthew M Weiss, Stephen A Hitchcock, Martin Citron, Wenge Zhong, Dean Hickman and Toni Williamson
Journal of Pharmacology and Experimental Therapeutics August 21, 2012, jpet.112.197954; DOI: https://doi.org/10.1124/jpet.112.197954
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