Abstract
N-Methylberbamine iodide and N-methylisotetrandine iodide were compared with d-tubocurarine chloride pentahydrate and d-O-methyltubocurarine iodide in rats, rabbits, cats, dogs, and man. N-Methylberbamine is approximately as active a paralyzing agent as d-tubocurarine, but differs in that it possesses fewer secondary effects. N-Methylisotetrandine, the O-methyl ether of N-methylberbamine, is less active than d-tubocurarine and much less active than d-O-methyltubocurarine, the most active agent of the group.
Footnotes
- Received May 14, 1949.
JPET articles become freely available 12 months after publication, and remain freely available for 5 years.Non-open access articles that fall outside this five year window are available only to institutional subscribers and current ASPET members, or through the article purchase feature at the bottom of the page.
|
Log in using your username and password
Purchase access
You may purchase access to this article. This will require you to create an account if you don't already have one.