Abstract
A procedure is presented for the estimation of gallium in biological material, useful in the range of 2 to 100 microgm. Ga in 10 gm. or less of sample. Chloroform extraction of Kjeldahl digestates after neutralization and treatment with 8-hydroxyquinoline offers a means of separating micro quantities of gallium and other metals from biological samples.
Gallium initially localized in the kidney and bone, with lesser amounts in the spleen, liver, brain and muscle. The bones act as storage depots and yield gallium slowly, where appreciable quantities still persist for as long as 60 days after a single injection of gallium lactate.
Footnotes
- Received December 15, 1948.
- 1949 by The American Society for Pharmacology and Experimental Therapeutics
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