XVIII. Metabolic Oxidation Products
Abstract
A study of the metabolism of nineteen 2-hydroxy-3-alkyl-1,4-naphthoquinones in human subjects has established that these substances suffer rapid and extensive degradation consisting in oxidation of the hydrocarbon side chain with the production of metabolites that are distinctly more hydrophilic than the compounds administered. Several of the metabolites were isolated and fully identified; they are secondary alcohols, tertiary alcohols, or carboxylic acids.
Footnotes
- Received June 7, 1948.
- 1948 by The American Society for Pharmacology and Experimental Therapeutics
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