Abstract
1. Niaara, an arrow poison from Colombia, S. A. is the latex of the tree Ogcodeia ternstroemiiflora Midbr.
2. An amorphous principle ("niaarin") having chemical and pharmacological properties characteristic of the cardiac glycosides has been isolated from the latex of this tree. Neither the crude nor pure materials have any curariform activity.
3. The intravenous LD50 in cats is 0.21 mgm./kgm. It is poorly absorbed from the gastro-intestinal tract.
4. Seven cases of congestive heart failure in man were successfully treated with niaarin.
Footnotes
- Received March 2, 1948.
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