p-Amino salicylic acid (PAS) was studied for its toxicity, fate in the body and chemotherapeutic efficacy in experimental tuberculosis, when used alone or in combination with streptomycin.
PAS has a relatively low acute toxicity, is well absorbed from the gastro intestinal tract, is well retained in the body for 3-5 hours, is nearly completely excreted in the urine within 24 hours, for the most part in the conjugated form, probably as the acetylated product. On continued administration there is evidence of cumulative action.
Pas has little therapeutic activity in rabbits infected with a bovine strain and in guinea pigs infected with a human strain of tubercle bacilli. Combined therapy with streptomycin showed no more than summation of effects, but gave no indication of potentiation, as was previously reported for sulfones and streptomycin (8).
- 1948 by The American Society for Pharmacology and Experimental Therapeutics