Abstract
1. Forty per cent of caronamide in dog plasma is bound on plasma protein at a drug concentration of 10 mgm. per cent and an albumin content of 3.5 grams per cent.
2. The overall renal clearance of caronamide in the dog is approximately one-half the filtration rate.
3. The average ratio of the clearance of caronamide, corrected for plasma binding, to glomerular filtration rate in 3 dogs is 1.30. The excretion of caronamide, therefore, is the result both of glomerular filtration and of some renal tubular excretion.
4. Evidence is presented for the occurrence of a metabolic product of caronamide in the plasma of 3 dogs, and in the urine of 2 of the 3 dogs.
5. Fifty-nine per cent of administered caronamide was recovered in the urine in a single experiment as caronamide. There was also evidence of an appreciable amount of caronamide metabolic product in the urine.
Footnotes
- Received July 22, 1947.
- 1946 by The American Society for Pharmacology and Experimental Therapeutics
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