Abstract
1. The activity of 10 cardiac glycosides and 5 esters of strophanthidin has been determined in cats by intravenous injection: adonitoxin, cymarol, sarmentosides A and B, cheirotoxin, convalloside, desgluco-hellebrin, evonoside; methyl and potassium cymarylates; 3-dimethyl-, 3-diethyl-, 3-di-n-propyl-, and 3-di-n-butyl-, aminoacetyl strophanthidins; and 3-chioroacetyl anhydrostrophanthidin.
2. The significance of certain structural changes has been pointed out.
3. The potency of 6 glycosides (adonitoxin, cymarol, cheirotoxin, sarmentoside A, convalloside, and desgluco-hellebrin) has also been determined in frogs, and compared simultaneously with that of cymarin or ouabain. The order of activity of these substances is frequently reversed between cats and frogs.
Footnotes
- Received May 5, 1947.
- 1946 by The American Society for Pharmacology and Experimental Therapeutics
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