Abstract
1. The pressor potency of 1-(p-hydroxyphenyl)-2-aminoethane (tyrarnine) is diminished by the addition of an hydroxyl group to the beta-carbon and by the addition of a methyl group to the nitrogen.
2. The replacement of one of the hydrogens of the amino group of 1-(p-hydroxyphenyl)-2-aminoethanol by ethyl, isopropyl, secondary butyl or tertiary butyl groups results in compounds that are strongly depressor in action. similar substitution by n-propyl, n-butyl and isobutyl groups results in compounds which exert only transient depressor action.
3. The presence of an alcoholic hydroxyl on the beta-carbon appears to be necessary for this action.
4. Those compounds which cause a prolonged fall in blood pressure are also most active in bringing about inhibition in those organs inhibited by epinephrine
Footnotes
- Received November 27, 1946.
- 1947 by The American Society for Pharmacology and Experimental Therapeutics
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