Abstract
1. Intravenous administration of appropriate single doses of alloxan to the hamster leads to necrosis of renal tubules, and to injury of the beta cells of the pancreatic islands with development of very high blood sugar levels.
2. Intravenous administration of single doses of senecionine to the hamster results in development of periportal necrosis of the liver.
3. Prolonged administration of sulfadiazine to the hamster does not result in severe renal injury, probably because the concentration of the conjugated form in the blood is so low. Slight hypertrophy of the thyroid and decrease of its colloid can be demonstrated.
4. Addition of thiouracil to the hamster's diet results in hypertrophy of the thyroid epithelium and diminution of colloid, but the effect seems to be less intense than in the rat.
Footnotes
- Received May 3, 1946.
JPET articles become freely available 12 months after publication, and remain freely available for 5 years.Non-open access articles that fall outside this five year window are available only to institutional subscribers and current ASPET members, or through the article purchase feature at the bottom of the page.
|