Abstract
1. Aggregation influences the toxicity of sympathomimetic amines in mice.
2. As the area per mouse increases, the toxicity decreases for mice confined in a group.
3. If the area per mouse is kept. constant at approximately 50 sq. cm., the presence of [9] other mice markedly increases the toxicity of these drugs.
4. Environmental temperature greatly influences the degree of mutual excitation and thus modifies the effect of aggregation on toxicity.
Footnotes
- Received January 24, 1946.
- 1946 by The American Society for Pharmacology and Experimental Therapeutics
JPET articles become freely available 12 months after publication, and remain freely available for 5 years.Non-open access articles that fall outside this five year window are available only to institutional subscribers and current ASPET members, or through the article purchase feature at the bottom of the page.
|
Log in using your username and password
Purchase access
You may purchase access to this article. This will require you to create an account if you don't already have one.