Abstract
1) The order of activity of several acridine compounds on the growth of E. coli on a synthetic medium has been determined.
2) Certain of the compounds in concentrations comparable to those that produce bacteriostasis inhibit the oxidation of glucose, pyruvic acid, lactic acid, asparagin and oleic acid.
3) The order of activity on the oxidative reactions is, however, different from that on growth.
4) Riboflavin does not antagonize the bacteriostatic action of these compounds.
Footnotes
- Received November 16, 1945.
- 1946 by The American Society for Pharmacology and Experimental Therapeutics
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