Abstract
Trasentin, Pavatrine, and Syntropan failed to alleviate experimental asthma induced in guinea pigs by exposing them to atomized histamine. Effective antispasmodic drugs in order of decreasing potency were: epinephrine, Benadryl, Demerol, atropine, papaverine, and aminophylline. The effect of drugs in experimental asthma should assist in selecting those with selective antispasmodic action on various types of smooth muscle.
Under the experimental conditions employed, bronchoconstriction referable to inhalation of histamine was not diminished by ergotamine tartrate, the local anesthetics, Procaine and Nupercaine, or by respiratory depressants such as morphine and pentobarbital.
Physostigmine and ephedrine increased the severity of the experimental asthma.
Footnotes
- Received July 16, 1945.
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