Abstract
1. An examination has been made of the therapeutic activity and toxicity of soluthiazole and solupyridine, disodium cinnamylidene dibisulphite derivatives of the parent compounds, sulphathiazole and sulphapyridine
2. They were equally active, and in streptococcal and pneumococcal (Type I) infections in mice were similar in activity to the sodium salts of the parent compounds, but against staphylococci they were less effective.
3. Solupyridine and soluthiazole were equal in toxicity to mice by all methods of administration, and were less toxic than the corresponding sodium salts of the parent compounds; they did not produce urolithiasis to any extent.
4. Tests for local toxicity and irritant properties indicated that the solutions were better tolerated than those of the sodium salts
Footnotes
- Received March 26, 1945.
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