Abstract
A comparison was made of some pharmacologic actions of pure quinidine, dihydroquinidine, and commercial quinidine sulfate, U.S.P. The following results were obtained:
1. The threshold doses of dihydroquinidine and quinidine required to raise the intensity of electrical stimulation needed to produce ventricular fibrillation in cats were approximately 1 and 3.5 mg. per kg., respectively.
2. In doses of 10 mg. per kg. intravenously into anesthetized cats, quinidine or dihydroquinidine caused a marked fall of blood pressure—almost of equal intensity. The duration of action of quinidine on blood pressure was more prolonged however. Doses of 1 to 2 mg. per kg. intravenously produced only slight and very transient fall of blood pressure.
3. From the median lethal doses obtained by intravenous injection into mice, dihydroquinidine was about 18% more toxic than quinidine.
Footnotes
- Received March 22, 1945.
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