Abstract
1. A series of tervalent and quinquevalent organic antimonials has been tested for toxicity, irritancy and trypanocidal activity, and the results assessed by accurate methods.
2. Trypanocidal activity has been determined by two methods, one depending upon the removal of trypanosomes from the peripheral blood, and the other upon the survival times of infected mice. Differences have been observed between the results in the case of phenyl stibonic acid derivatives.
3. The properties investigated are shown to be independent of antimony content, but to have some correlation with one another and with the initial rate of excretion of the antimony.
Footnotes
- Received March 2, 1944.
JPET articles become freely available 12 months after publication, and remain freely available for 5 years.Non-open access articles that fall outside this five year window are available only to institutional subscribers and current ASPET members, or through the article purchase feature at the bottom of the page.
|
Log in using your username and password
Purchase access
You may purchase access to this article. This will require you to create an account if you don't already have one.