Abstract
Surface-active choline esters were prepared by balancing the highly polar quaternary ammonium group in carbamylcholine with non-polar groups at the carbamyl end of the molecule. The new compounds, e.g., di-n-butyl-carbamylcholine chloride, have an atropine-like action on the ocular muscles rather than the muscatine- and nicotine-like effects characterizing previously known choline esters.
Di-n-butyl-carbamylcholine has short action and a proportionately greater effect on accommodation than on the pupil while atropine has more prolonged action and a greater effect on the pupil. The new drugs and atropine act synergistically on the iris sphincter.
Footnotes
- Received November 22, 1943.
JPET articles become freely available 12 months after publication, and remain freely available for 5 years.Non-open access articles that fall outside this five year window are available only to institutional subscribers and current ASPET members, or through the article purchase feature at the bottom of the page.
|
Log in using your username and password
Purchase access
You may purchase access to this article. This will require you to create an account if you don't already have one.