Abstract
The excretion of morphine sulfuric ether, and in some instances its potassium salt, has been studied in 9 non-tolerant and 2 tolerant dogs, and in 2 non-addicts, 1 addict, and 10 post-addicts. It is excreted in urine as both free and bound morphine, the amounts of which are somewhat lower than that reported for morphine per se.
Its pharmacological activity is of a low order; it does not produce euphoria in man or relieve pain. Neither can it be substituted for morphine in addicts nor does it relieve withdrawal symptoms. Its pain-threshold raising effect as determined by Hardy, Wolff, and Goodell technique is practically absent in man and is questionable in dogs.
Footnotes
- Received November 15, 1943.
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