Abstract
The compounds, p-aminoacetophenone and p-aminopropiophenone, whether given orally or intravenously, are highly active in forming methemoglobin. The latter is the more active, being as active as p-dinitrobenzene, but differing in that its effect is less rapid and more prolonged. Death occurs at 95% methemoglobinemia and recovery may occur with 87% methemoglobinemia. Due to the desirable chemical and pharmacological properties of p-aminopropiophenone this compound may prove of value for the experimental production of methemoglobinemia and anoxia.
Footnotes
- Received August 19, 1943.
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