Abstract
Procedures are outlined for fractionating and concentrating renal extracts which, in relatively small doses administered orally, effectively reduce the blood pressure of hypertensive rats. The solubility of the active principle in water and aqueous solutions of organic solvents and the behavior of the extracts toward various precipitants (picric acid, ammonium sulfate, etc.) are described. The dialyzability of the active principle differentiates it from the agent described by other workers as effective following parenteral administration.
Footnotes
- Received January 15, 1943.
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