I. DETOXICATION BY MEANS OF p-AMINOBENZOIC ACID OF CERTAIN PENTAVALENT ARSENICAL DRUGS GIVEN IN MASSIVE DOSES TO RATS
Abstract
1. p-aminobenzoic acid has been found highly effective in reducing fatalities among rats to which high, acutely poisonous doses of Carbarsone, Acetarsone, "Tryparsamide", arsanilic acid, and phenyl arsonic acid have been administered. No close structural similarity exists between these several phenyl arsonates and p-aminobenzoic acid.
2. Detoxication is independent of the route whereby either the phenyl arsonic compound or the p-aminobenzoic acid is given.
3. No inhibition by p-aminobenzoic acid of the trypanocidal action of Carbarsone, "Tryparsamide" or arsanilic acid (= "Atoxyl") was detected in rats infected with Trypanosoma equiperdum.
Footnotes
- Received February 26, 1943.
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