Abstract
1. Six synthetic glycosides, namely, digitoxigenin-β-, digitoxigenin-β-tetraacetyl-, digoxigenin-β-, digoxigenin-β-tetraacetyl-, periplogenin-β-, and periplogenin-β-tetraacetyl-d-glucosides, have been studied pharmacologically and compared with their corresponding natural glycosides and aglycones—digitoxin, digitoxigenin, digoxin, digoxigenin, periplocymarin, and periplogenin.
2. In cats, digitoxigenin-, digoxigenin-, and periplogenin-β-d-glucosides are more powerful than digitoxin, digoxin, and periplocymarin, respectively. All the tetraacetyl derivatives have a low potency.
3. In frogs, the results are less uniform. While digitoxigenin- and digoxigenin-β-d-glucosides are more active than digitoxin and digoxin, respectively, periplogenin-β-d-glucoside is weaker than periplocymarin. There is also suggestion that digoxigenin-β-tetraacetyl-d-glucoside is more active than digoxigenin.
4. Periplogenin is decidedly less potent than periplocymarin, indicating the favorable influence of the sugar component in the molecule of the glycoside.
Footnotes
- Received January 20, 1943.
JPET articles become freely available 12 months after publication, and remain freely available for 5 years.Non-open access articles that fall outside this five year window are available only to institutional subscribers and current ASPET members, or through the article purchase feature at the bottom of the page.
|