Abstract
Atropine, scopolamine, light anesthesia, abdominal binding, and conditioning by previous tumbling were treatments found to be effective in protecting rats against lethal damage induced by tumbling in the Noble-Collip apparatus. Physostigmine sensitized animals to Noble-Collip damage. These and other therapeutic data emphasize the involvement of cholinergic components of the autonomic nervous system in such damage.
The involvement of the parasympathetic nervous system, considered in relation to factors involved in the violent tumbling characteristic of the Noble-Collip procedure, suggests that the acceleration-deceleration effect is an important component of Noble-Collip injury. Confirmation of this view was obtained by subjecting rats to rapid up-and-down shaking in a device designed to eliminate the type of gross trauma induced by Noble-Collip tumbling. Measures found effective in protecting rats from damage due to tumbling were also effective against shaking.
Footnotes
- Received September 23, 1942.
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