Abstract
1. Nicotine has been determined quantitatively in human urine by a modified silicotungstic acid method.
2. During the periods when the urine was alkaline, the amount of nicotine excreted by tobacco smokers was only 25% of that noted when the urine was acid, presumably because of reabsorption of the nicotine from the urinary tract.
3. Data are presented supporting the view that some potent mechanism other than urinary excretion is active in the disposal of nicotine by tobacco smokers.
4. In studies of the quantitative urinary elimination of chemicals generally the possible influence of urinary pH on their resorption from the urinary tract might well be borne in mind.
Footnotes
- Received July 31, 1942.
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