Abstract
1. Avertin administered rectally to rabbits in sub-lethal doses or in lethal doses which are effectively antidoted by picrotoxin so as not to cause acute death by systemic intoxication, produces a delayed death by rectal irritation, inflammation, ulceration and sometimes perforation.
2. This intestinal lesion is associated with analogous degenerative visceral changes chiefly in the heart, the kidney, the brain, and the liver.
3. The immediate cause of death is either perforation of the intestine followed by peritonitis or excruciating pain on defecation.
Footnotes
- Received March 9, 1942.
JPET articles become freely available 12 months after publication, and remain freely available for 5 years.Non-open access articles that fall outside this five year window are available only to institutional subscribers and current ASPET members, or through the article purchase feature at the bottom of the page.
|
Log in using your username and password
Purchase access
You may purchase access to this article. This will require you to create an account if you don't already have one.