Abstract
1. Yohimbine antagonizes the action of adrenalin upon the excised dilator iridis of albino rabbits, without reversing the adrenalin effect.
2. Yohimbine, when used alone, has no discernible influence upon the dilator.
3. Ergotamine is a powerful antagonist of adrenalin and can reverse the normal effect of a subsequent application of the latter drug.
4. Ergotamine, when used alone, has a slight, inconsistent stimulating effect upon the dilator.
5. Ergotamine, even though it contracts the dilator, does not act synergistically with adrenalin.
Footnotes
- Received October 23, 1941.
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