Abstract
1. The acute toxicity of monocrotaline and retronecine has been determined in mice.
2. Monocrotaline produces liver necrosis associated with sinusoidal congestion and hemorrhage into necrotic cell cords. Repeated administration of monocrotaline appears to cause hypertrophy of liver cells.
3. Intravenous injection of large doses of retronecine is followed by either rapid death or complete recovery. No hepatic injury has resulted.
4. Monocrotaline inhibits isolated rabbits' intestines, and has a slight depressor action in cats. Retronecine reduces cats' blood pressure in relatively large doses, and stimulates the isolated guinea pig's uterus. In dilute concentration, retronecine inhibits isolated rabbits' intestines, but in stronger solutions, it augments them.
Footnotes
- Received February 2, 1942.
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