Abstract
A series of 27 sympathomimetic amines has been tested for their effect on pancreatic secretion. Twenty-one of these compounds inhibited the secretion evoked by continuous secretin stimulation. The mechanism whereby this took place is probably on a vasoconstrictor basis. Seven of the compounds stimulated pancreatic secretion; these were all structurally similar to the extent of hydroxylation of the benzene ring in specific positions, an unsubstituted carbon atom in justaposition to the ring, and a primary or secondary amino nitrogen. Methylation of the hydroxyl groups leaves the secretory potency attenuated but not abolished. The type of stimulation evidenced by these compounds differs from secretin stimulation.
Footnotes
- Received December 15, 1941.
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