Abstract
1. Both calcium and strontium acetates increased the duration of sodium pentobarbital anesthesia when the salts were given in equimolecular quantities by intraperitoneal injection.
2. Calcium acetate increased the duration of sodium pentobarbital anesthesia when given by vein. Strontium acetate had very little if any effect.
3. Calcium acetate was more toxic to the rat by intraperitoneal injection than strontium acetate.
4. The greater toxicity of the calcium by intraperitoneal injection was shown to be associated with an increased hemoglobin concentration of the blood.
5. Sodium pentobarbital decreased the toxicity of strontium acetate but strontium acetate did not decrease the toxicity of sodium pentobarbital.
Footnotes
- Received August 1, 1941.
JPET articles become freely available 12 months after publication, and remain freely available for 5 years.Non-open access articles that fall outside this five year window are available only to institutional subscribers and current ASPET members, or through the article purchase feature at the bottom of the page.
|
Log in using your username and password
Purchase access
You may purchase access to this article. This will require you to create an account if you don't already have one.