Abstract
1. In the present experiments the hydrochlorides of α-morpholino methyl-β naphthol (I), α-piperidino methyl-β-naphthol (II), β-piperidino methyl α-naphthyl p-aminobenzoate (III), β-morpholino methyl α-naphthyl p-aminobenzoate (IV), α-morpholino methyl β-naphthyl p-aminobenzoate (V), α-piperidino-methyl β-naphthyl benzoate (VI) and α-piperidino methyl-β-naphthyl p-aminobenzoate (VII) were found to produce local anesthesia.
2. Compounds I and II produced marked anesthesia intracutaneously in guinea-pigs but caused irritation. Compound II also was more toxic than procaine subcutaneously in guinea pigs. Compounds III, IV and V are very unstable in solution and produce anesthesia of poor depth and variable duration.
3. Compounds VI and VII produced marked anesthesia and VII was found to have an extremely low subcutaneous toxicity. Both compounds produced irritation in corneal and intradermal tests.
Footnotes
- Received May 6, 1941.