Abstract
Intravenous injections of sedative drugs had the following effects on the pial arteries of anesthetized animals:
1. Dial caused chiefly dilation, but the effect was neither constant nor large.
2. Avertin fluid (avertin crystals plus amylene hydrate and water) caused dilation. This response was fairly consistent and of large extent.
3. Avertin crystals (aqueous solution) caused dilation. Occasionally this was followed by a slow constriction of relatively long duration.
4. Amylene hydrate caused dilation, but this was usually complicated by a change in blood pressure.
5. Acetanilide caused no change in calibre, but a definite change in color of the blood in the pial vessels. This change was from red to brownish red with a purple tint—suggestive of cyanosis.
6. Sodium bromide (injected intravenously at ordinary rate) caused no change in diameter of the pial arteries.
Footnotes
- Received April 12, 1941.
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