Abstract
1. The digitalis derivatives, K-strophanthin, ouabain and digifoline at times have a direct coronary constrictor action even in therapeutic doses.
2. Metrazol and glucose are mild direct coronary dilators.
3. Calcium gluconate, in contrast with the chloride salt which is a powerful dilator of the coronary vessels, does not cause any constant or striking change in coronary caliber except that a mild dilatation occurs with large doses.
4. Aminophyllin and caffein sodium benzoate are consistently direct coronary dilators, the aminophyllin being the more powerful.
5. Papaverine hydrochloride is a powerful long-lasting direct coronary dilating agent. This and its tendency to prevent ventricular fibrillation probably explain its clinical benefits.
Footnotes
- Received April 25, 1941.
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