Abstract
It was found that both the mydriatic and the hyperthermal effects produced by ergometrine in the rabbit are quantitatively related to the dose and thus either may serve as a basis for the quantitative estimation of this drug.
When both of these effects are considered simultaneously qualitative properties are acquired in addition. It is then possible to distinguish between the results produced by ergometrine and those of ergotoxine.
Effective doses of ergometrine were found to be less toxic than those of ergotoxine.
Using 16 rabbits for an assay, limits of error of about ± 20 per cent may be expected.
Footnotes
- Received January 11, 1941.
Log in using your username and password
Pay Per Article - You may access this article (from the computer you are currently using) for 1 day for US$35.00
Regain Access - You can regain access to a recent Pay per Article purchase if your access period has not yet expired.