Abstract
Fourteen members of a series of N4-acylsulfanilhydroxamides and four related compounds have been tested for chemotherapeutic activity. Three of the derivatives, n-valeryl, n-hexanoyl and n-heptanoyl, possess a high degree of efficacy in combating experimental streptococcal infections in mice. They have also been found to be effective against a strain of meningococcus.
Blood concentrations of N4-hexanoylsulfanilhydroxamide, sulfanilamide and sulfapyridine have been determined in mice and correlated with chemotherapeutic activity.
Footnotes
- Received October 10, 1940.
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