Abstract
The administration of estradiol, testosterone, desoxycorticosterone, progesterone and diethylstilboestrol to normal rats induced in some animals an elevation of blood pressure to hypertensive levels. It is suggested that this hypertensive effect is due to renal injury since it could be abolished by the administration of renal extracts and since other evidence points to changes occurring in the kidney following the use of these substances. The occurrence of hypertension in certain cases of Cushing's disease or of the adreno-genital syndrome is attributed to the formation of abnormal steroid products. The naturally occurring adrenal cortical hormone was found to be devoid of the pressor and toxic effects observed following the injection of desoxycorticosterone.
Footnotes
- Received April 1, 1940.
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