Abstract
1. Epinephrine vasomotor reversal in dogs is commonly observed after the administration of 1,2,3,4-tetrahydroisoquinolines with either secondary or tertiary amine nitrogens. This property is, however, sometimes absent and an occasional compound even sensitizes the blood pressure to epinephrine.
2. In general, the isoquinolines with the tertiary amine nitrogens are more effective than those with the secondary amine. The methoxy derivatives are more active than the ethoxy compounds. The 2-alkyl, but otherwise unsubstituted, derivatives are the most powerful of the isoquinoline adrenolytic agents investigated.
3. Quantitatively and qualitatively the more active of the 2-alkyl-tetrahydroisoquinolines compare favorably with ergotoxine, F 883, F 933 and yohimbine in causing adrenolysis.
4. The adrenolytic property of 2-methyl-tetrahydroisoquinoline is apparently unaffected by the anesthetic employed for it was found present when dial, nembutal or chloralose were used.
Footnotes
- Received July 26, 1939.
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