Abstract
1. Morphine effect is potentiated by Prostigmin when pressure-pain responses in the cat are determined.
2. Atropine antagonizes the effect of morphine or of a morphine-Prostigmin combination.
3. Evidence is presented to show that morphine fits many of the postulates necessary for a cholinergic drug.
4. Statistical analyses as to probability ("P") correlate well with result averages.
5. The mechanism of morphine action as an acetylcholine-like drug is discussed.
6. Practical application of these results is suggested.
Footnotes
- Received July 28, 1939.
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