Abstract
Dial was used to produce surgical anaesthesia repeatedly in seven dogs. Three dogs developed a tolerance such that the dose which first produced anaesthesia lasting for at least eight hours, later induced anaesthesia of only an hour or less duration.
Nembutal was used to produce surgical anaesthesia repeatedly in five dogs. The duration of the second anaesthesia might drop as low as one half the initial, but thereafter as many as fifty-three successive injections of the same dose over a period of 83 days produced approximately the same duration of anaesthesia. The duration of anaesthesia was proportional to the dose used.
Footnotes
- Received October 18, 1937.
JPET articles become freely available 12 months after publication, and remain freely available for 5 years.Non-open access articles that fall outside this five year window are available only to institutional subscribers and current ASPET members, or through the article purchase feature at the bottom of the page.
|
Log in using your username and password
Purchase access
You may purchase access to this article. This will require you to create an account if you don't already have one.