Abstract
1. Intra-arterial injections of acetyl choline produce regular salivary secretion which endures exactly as long as the injection.
2. Histamine administered in the same way may, or may not produce a secretion.
3. A histamine secretion once started tends to continue as long as histamine is administered.
4. A histamine secretion is potentiated by physostigmine and obliterated by atropine.
5. Intra-arterial administration of histamine causes marked potentiation of the effects of chorda stimulation. It has no such effect on intra-arterially administered acetyl choline.
6. The mechanism of histamine secretion is discussed and it is suggested that this depends on histamine producing a continuation of the effects of a stimulus of the cholinergic nerves.
Footnotes
- Received May 28, 1937.
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