Abstract
Five pairs of compounds of the morphine series are compared in each of which one member differs from the other only in the muzzling of the alcoholic hydroxyl by methylation.
Methylation of the alcoholic hydroxyl like methylation of the phenolic hydroxyl increases toxicity and convulsant action and decreases emetic effect. The former chemical change unlike the latter increases analgesic and exciting effects in the cat and depressant action in the rat.
Footnotes
- Received June 17, 1935.
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