Abstract
1. Tissue extract produced a contraction of all segments of the intestine of guinea pigs, but did not contract the intestine of rats or rabbits.
2. Tissue extract caused contraction only in alkaline solutions, relaxation occurring when the reaction of the solutions was slightly acid.
3. The action of tissue extract on the guinea pig, rat, and rabbit intestines was similar to that of histamine.
4. The active principle of tissue extract is not acetylcholine or methylguanidine.
5. Permutit absorbed the active principle of tissue extract as well as that of histamine.
Footnotes
- Received May 4, 1934.
JPET articles become freely available 12 months after publication, and remain freely available for 5 years.Non-open access articles that fall outside this five year window are available only to institutional subscribers and current ASPET members, or through the article purchase feature at the bottom of the page.
|
Log in using your username and password
Purchase access
You may purchase access to this article. This will require you to create an account if you don't already have one.