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Research ArticleArticle

CARBAZOL DERIVATIVES I. LOCAL ANESTHETICS OF URETHANE TYPE

P. K. KNOEFEL
Journal of Pharmacology and Experimental Therapeutics January 1933, 47 (1) 69-78;
P. K. KNOEFEL
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Abstract

Substituted aminoalkyl esters of carbazol-N-carboxylic acid have high local anesthetic activity, and in general, low toxicity. The presence of a urethane linkage appears to reduce the stimulant effect on the central nervous system that most local anesthetics possess, and to contribute a primary depressant effect. The most promising compound of the series (diethylaminoethyl carbazol-N-carboxylate, Carbacaine) has pressor activity, is absorbed slowly from subcutaneous tissues, and is detoxified more rapidly than cocaine. The use of the citrate as a soluble salt of carbacaine base, rather than the hydrochloride reduces the local irritation and confers stability.

Footnotes

    • Received May 16, 1932.

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Journal of Pharmacology and Experimental Therapeutics
Vol. 47, Issue 1
1 Jan 1933
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Research ArticleArticle

CARBAZOL DERIVATIVES I. LOCAL ANESTHETICS OF URETHANE TYPE

P. K. KNOEFEL
Journal of Pharmacology and Experimental Therapeutics January 1, 1933, 47 (1) 69-78;

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Research ArticleArticle

CARBAZOL DERIVATIVES I. LOCAL ANESTHETICS OF URETHANE TYPE

P. K. KNOEFEL
Journal of Pharmacology and Experimental Therapeutics January 1, 1933, 47 (1) 69-78;
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